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KMID : 0981420000020010121
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Schizophrenia Clinics
2000 Volume.2 No. 1 p.121 ~ p.136
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Cerebellar Function in Schizophrenia
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Kim Jae-Jin
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Abstract
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The cerebellum is not limited to a role in the coordination of movement as known up to now, but serves as a coordinator of diverse non-motor cognitive functions. This cerebellar contribution to cognitive operations is corresponded to its anatomical characteristics ; the cerebellum possesses a unique cellular architecture that makes it adequate for performing a timing function and extensive connections with cerebral cortices by feedforward and feedback limbs. An abnormality in the cere brocere be liar circuitry, there-fore, may produce a poor coordination in the motor and non-motor cognitive process, which leads to diverse cognitive deficits and clinical symptoms. It provides a theoretical framework for a unitary model that schizophrenia may be a single disorder explained by a single phenotype and a common pathophysiology. A unitary model in schizophrenia suggests that a single fundamental unifying process is mediated between multiple etiology and diverse symptoms. ´Loosening of association´ Nvas a fundamental cognitive problem in Bleuler´s concept. Likewise, a fundamental deficit in schizophrenia is ´cognitive dysmetria´ which is produced by a dysfunction in the cortico-ce re bellar- thalamic -cortical circuit(CCTCC) and defined as a kind of ´misconnection syndrome´ in terms of an aspect of dysfunctional distributed neural circuits.
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KEYWORD
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Cerebellum, Cognitive dysmetria, Schizophrenia
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